ArticleJournal of neuroradiology = Journal de neuroradiologie2026
Arterial spin labeling MRI with multiple post-labeling delays reveals interictal hypo- and hyper-perfusion patterns in epilepsy: A proof of concept.
Article in Journal of neuroradiology = Journal de neuroradiologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
background and purposeInterictal cerebral blood flow (CBF) may be useful for seizure focus localization. However, its accuracy is debatable. Studies suggested interictal hypoperfusion at the seizure focus, yet others suggested hyperperfusion. This study aims to investigate the patterns of interictal perfusion in epilepsy subjects compared to healthy controls using multiple labeling-delays arterial spin labeling MRI, and to explore the accuracy of perfusion estimation using single post-labeling delay arterial-spin labeling MRI by comparing it to multiple post-labeling delays arterial-spin labeling MRI. MATERIALS AND
methodsWe analyzed CBF in 40 participants, 15 healthy (35.9 ± 9.5 years, 47% women) and 25 epilepsy (41.1 ± 10.5 years; 52% women). We acquired a multiple post-labeling delays arterial spin labeling MRI using Hadamard encoding, and structural MRI. Perfusion quantification was performed using in-house software and analyzed using surface-based method. Z-scores of CBF and its absolute value (|Z-score|) were calculated to evaluate abnormal perfusion.
resultsBrain perfusion showed interictal hypo- and/or hyper-perfusion in epilepsy compared to healthy participants involving focal to whole brain alterations. Epilepsy subjects had higher |Z-score| in most cortical regions compared to the healthy group. CBF generated from single post-labeling delay arterial-spin labeling MRI correlated with ones from multiple post-labeling delays in most cortical regions, yet the level of correlation was affected by regional arterial transit time and the labeling scheme. In regions with shorter arterial transit time, correlation peaked at shorter post-labeling delay (1300ms); whereas in regions with longer arterial transit time, correlation peaked at longer post-labeling delay (2250ms).
conclusionsOur findings suggest that the interictal CBF may fluctuate between hypo- and hyper- perfusion, and the involvement of brain regions may extend well beyond the seizure focus. Additionally, while single-post-labeling delay is efficient and clinically feasible, the accuracy of its assessment of perfusion depends on brain regions and the labeling scheme.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.