ArticleJournal of clinical periodontology2026
The Effect of Adjunctive Systemic Antibiotics on the Outcomes of Non-Surgical Periodontal Therapy: A Retrospective Cohort Study.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Systemic Antibiotics as Adjuncts in Periodontal Therapy for Stage III and Stage IV Periodontitis: An Umbrella Review Aligned with the 2018 World Workshop Classification, with AMSTAR-2 Critical Appraisal.Antibiotics (Basel, Switzerland) · 2026Review
- Screening for undiagnosed hyperglycemia in patients with periodontitis: a cross-sectional study.Einstein (Sao Paulo, Brazil) · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
aimTo evaluate the real-world comparative effectiveness of various adjunctive systemic antibiotic regimens in combination with scaling and root planing (SRP) using a large, multi-centre retrospective cohort. MATERIALS AND
methodsElectronic health records were used retrospectively to categorise periodontitis patients into 'SRP Only' or 'SRP + Antibiotic' groups based on prescriptions within 7 days of therapy. Primary outcomes included changes in probing depth (PD), clinical attachment level (CAL), percentage of sites with PD ≥ 4 mm and bleeding on probing (BOP). Secondary outcomes assessed tooth-level worsening in mobility or furcation status.
resultsAmong 3125 patients, the amoxicillin + metronidazole combination was found to be statistically superior to SRP alone for reducing PD, BOP and residual disease burden. It significantly reduced the odds of worsening tooth mobility by 63% and furcation involvement by 50%. While azithromycin and doxycycline improved CAL, the benefits of the amoxicillin + metronidazole combination were most pronounced in Stage III/IV (severe) periodontitis (-11.4% residual burden reduction, OR 4.55 for clinical success), compared to a modest effect in Stage I/II disease (-3.8%, p = 0.030).
conclusionAdjunctive systemic antibiotics, particularly the amoxicillin + metronidazole combination, significantly enhance clinical outcomes in non-surgical periodontitis treatment compared to SRP alone, with the greatest benefits seen in severe disease.
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