Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
23 authors.
Florian RachenneMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.
Norman SchneiderMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0009-0007-4576-2163
Félix Rey-CadilhacMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.
Idalba Serrato-PomarMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.
Lauryne PruvostMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0000-0002-0199-521X
Laura Di PietroMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0009-0009-7273-4832
Jacques DainatMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0000-0002-6629-0173
Audrey VernetPlant Health Institute of Montpellier, University of Montpellier, Institut of Research for development, Montpellier 34398, France.
Chantal CazevieilleInstitute for Neurosciences of Montpellier, Electronic Microscopy Platform, Saint Eloi Hospital, Montpellier 34091, France.ORCID 0000-0003-4113-1309
Aurélie AncelinCentre de Biologie Structurale, Electronic Microscopy Platform, CNRS, Montpellier 34090, France.
Joséphine Lai Kee HimCentre de Biologie Structurale, Electronic Microscopy Platform, CNRS, Montpellier 34090, France.ORCID 0000-0001-6303-1224
Sander JansenKatholic University Leuven, Department of Microbiology, Immunology and Transplantion, Rega Institute, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven BE-3000, Belgium.
Elliott F MiotMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0000-0003-3078-8719
Jérémy FraeringPlateforme Protéomique Strasbourg-Esplanade, CNRS UAR1589, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Strasbourg 67000, France.ORCID 0000-0001-6305-6800
Laurianne SimonInstitut Charles Gerhardt Montpellier, University of Montpellier, CNRS, Ecole Nationale Supérieure de Chimie de Montpellier, Montpellier 34293, France.ORCID 0000-0002-8515-947X
Dorothée MisséMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0000-0002-6485-3841
Marie MorilleInstitut Charles Gerhardt Montpellier, University of Montpellier, CNRS, Ecole Nationale Supérieure de Chimie de Montpellier, Montpellier 34293, France.ORCID 0000-0001-8224-7346
Philippe HammannPlateforme Protéomique Strasbourg-Esplanade, CNRS UAR1589, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Strasbourg 67000, France.ORCID 0000-0002-6883-9203
Martial SevenoBioCampus Montpellier, University of Montpellier, CNRS, INSERM, Montpellier 34293, France.ORCID 0000-0002-5000-8735
Serge UrbachInstitut de Génétique Fontionnel, University of Montpellier, CNRS, INSERM, Montpellier 34000, France.ORCID 0000-0001-8663-2006
Kai DallmeierKatholic University Leuven, Department of Microbiology, Immunology and Transplantion, Rega Institute, Laboratory of Molecular Vaccinology and Vaccine Discovery, Leuven BE-3000, Belgium.ORCID 0000-0002-8117-9166
Éric MaroisInstitute of Molecular and Cellular Biology, University of Strasbourg, CNRS, Inserm, Strasbourg 67200, France.ORCID 0000-0003-4147-3747
Julien PomponMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Controle, University of Montpellier, Institut of Research for development, CNRS, Montpellier 34394, France.ORCID 0000-0003-1110-9039
Funding
Agence Nationale de la Recherche (ANR) ANR-20-CE15-0006CBS2 doctoral school fellowshipEC | HORIZON EUROPE Framework Programme (Horizon Europe) 101137006EU RIA Health Action 101137459Fonds Wetenschappelijk Onderzoek (FWO) 30981113
6 · The paper itself
Abstract
Viruses exploit extracellular vesicles (EVs) to transfer infection-enhancing viral RNAs. However, mechanisms underlying viral RNA loading remain elusive. We leveraged our previous discovery that dengue virus secretes transmission-enhancing subgenomic flaviviral RNA (sfRNA) into mosquito salivary EVs to investigate viral RNA loading mechanism. We demonstrate that sfRNA alone promotes the secretion of sfRNA-containing EVs marked by the mosquito EV biogenesis protein AeSyntenin, by applying microscopy and viral genetic editing in in vitro and in vivo models. SfRNA via its stem loop structures interacts intracellularly with mosquito AeSyntenin and this interaction is selectively maintained within EVs as shown by complementary RNA-affinity chromatography and RNA immunoprecipitation, and AI-based prediction. Finally, we used systemic and salivary gland-specific protein depletion to establish a functional role for mosquito AeSyntenin in exosome production and salivary secretion of sfRNA. We propose that sfRNA binds AeSyntenin to drive its selective packaging and release into exosomes, elucidating a mechanism for viral RNA incorporation into EVs.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes. · full record | OpenQuestion