ArticleProceedings of the National Academy of Sciences of the United States of America2026
High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Rebeka Fanti, Esther Wolf, Tatsuya Ikenoue, Justin C Deme, Swati Balakrishnan, Brandon A Keith, Matthew G Alteen, Renu Chandrasekaran, Manisha Yadav, Ritika Bhajiawala and 8 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Rebeka Fanti *Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0001-9995-5875 Esther Wolf *Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.
Tatsuya IkenoueDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Justin C DemeCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0000-0001-8811-9871 Swati BalakrishnanStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-2903-0604 Brandon A KeithStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.
Matthew G AlteenStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-9639-7668 Renu ChandrasekaranStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0001-7593-2476 Manisha YadavStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0001-6559-7774 Ritika BhajiawalaStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.
Suzanne AcklooStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.
Aled M EdwardsStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-4782-6016 Derek J WilsonDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.
Susan M LeaCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Hiroaki SugaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-5298-9186 Rachel J HardingStructural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-1134-391X Funding
Canadian Institutes of Health Research (CIHR) 198025EUbOPEN: Enabling and Unlocking biology in the OPEN 875510MEXT | Japan Society for the Promotion of Science (JSPS) JP20H05618Mitacs (Mitacs Inc.) IT21124Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2024-05769
6 · The paper itselfAbstract
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a Cytosine-Adenosine-Guanine (CAG) repeat expansion in the
Indexed as
Huntingtin ProteinMacrocyclic CompoundsPeptidesAnimalsHumansHuntington DiseaseNuclear ProteinsProtein BindingHAP40 protein, humanHTT protein, humanHuntingtin ProteinMacrocyclic CompoundsNuclear ProteinsPeptidesHAP40HuntingtinHuntington diseasemacrocycles
Identifiers
PMID41838909
PMCPMC13012115
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