Trial reportPloS one2026
Helping primary care providers recognize and respond to medication non-adherence and drug-drug interactions: A randomized-controlled clinical utility trial in a value-based care setting.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05658653 (Measuring the Clinical Utility of Aegis's Chronic Disease Management Test Among VillageMD Providers), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measuring the Clinical Utility of Aegis's Chronic Disease Management Test Among VillageMD Providers: A CPV Randomized Control Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the clinical utility of a novel chronic disease management test among primary care providers practicing in a value-based care setting. The study assessed the ability of primary care providers to recognize and respond to medication nonadherence (MNA), drug-drug interactions (DDIs), and disease progression.
designA pre-post experimental randomized controlled trial of primary care providers in the same practice setting caring for simulated patients with chronic disease. SETTING AND
participants139 licensed primary care providers (MD, DO, NP, or PA) at a large, multi-state primary care practice in the United States.
interventionBoth intervention and control group participants cared for three simulated chronic disease patients at baseline and again after the intervention. After baseline, intervention group participants reviewed educational materials about a new saliva-based chronic disease management test that detects MNA and DDI and were then provided with the test's results in simulation; the control group did not have access to the test results. PRIMARY OUTCOME MEASURES: Changes in care decisions between the two groups were analyzed using a difference-in-differences approach to determine whether routine testing in the outpatient setting changed correct identification and management of medication nonadherence (MNA), drug-drug interactions (DDI), and disease progression.
resultsThe intervention group participants were significantly more likely to make the correct diagnosis of MNA (control: 10.0% vs intervention: 80.0%, p < 0.001) and DDI (control: 18.6% vs intervention: 52.9%, p < 0.001) and to recommend an appropriate treatment for MNA (control: 25.7% vs intervention: 54.3%, p = 0.001) and DDI patients (control: 27.1% vs intervention: 58.8%, p < 0.001).
conclusionPrimary care providers with results from a definitive saliva-based test for MNA and DDI were significantly more likely to identify those common challenges and make appropriate updates to the patient's treatment plan. This has important implications for improving quality and value, especially for the millions of patients with chronic conditions on multiple medications.
trial registrationClinicalTrials.gov, NCT05658653, Registered 2-Dec-2022.
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