ArticleSTAR protocols2026
Protocol for constructing an orthotopic mouse model of metastatic renal cell carcinoma.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Renal cancer is characterized by an insidious onset and a high tendency for lung metastasis in advanced stages. Here, we present a protocol for constructing an orthotopic mouse model that recapitulates the spontaneous metastasis process of human renal cell carcinoma (RCC). We describe steps for dynamically monitoring tumor growth and metastasis by in vivo bioluminescence imaging. We then detail the procedures for performing histopathological analyses. This protocol provides a reliable preclinical platform for investigating RCC metastasis mechanisms and evaluating anti-metastatic therapies. For complete details on the use and execution of this protocol, please refer to Shi et al.
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