Evidence map›Paper›PMID 41838692›Full record

ArticlePloS one2026

Alterations in bone malformation in the absence of the endosomal SNAREs Vti1a and Vti1b.

Simone Schmücker, Susanne Schöning, Christiane Wiegand, Sascha Michael Höfling, Christian Bollmann, Judith Koliwer, Gabriele Fischer von Mollard

Abstract read
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In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simone SchmückerBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Susanne SchöningBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Christiane WiegandBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Sascha Michael HöflingBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Christian BollmannBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Judith KoliwerBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Gabriele Fischer von MollardBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0000-0003-3236-1401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Qb-SNAREs (soluble N-ethylmaleimide-sensitive-factor attachment receptor) Vti1a and Vti1b participate in membrane fusion in the endosomal system of mammalian cells and are partially redundant. While double deficiency of Vti1a-/-Vti1b-/- (DKO) is perinatal lethal, double heterozygous Vti1a+/-Vti1b+/- (DHET) mice presented no phenotypic alterations when compared to wild-type mice. To investigate the physiological role of these proteins, this study focused on the analysis of embryonic DKO versus DHET mice. The size and weight of E18.5 DKO embryos were significantly lower when compared with those of DHET littermates and wild-type embryos. Furthermore, we observed alterations in skeletal development of DKO embryos, mainly in the front limbs, ribs, clavicles and sternum. A lumbar vertebra was missing in DKO embryos and the palate was not closed in 50% of these embryos.

Indexed as

Bone and BonesEndosomesAnimalsEmbryo, MammalianFemaleMiceMice, Knockout

Identifiers

PMID41838692
PMCPMC12991266

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.