Evidence map›Paper›PMID 41838618›Full record

ArticleJournal of medicinal chemistry2026

Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors.

Shuang Chen, Muchen Yu, Manming Xu, Sergio Decherchi, Magdalena A Taracila, Andrea M Hujer, Christopher R Bethel, Robert A Bonomo, Shozeb Haider

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuang ChenDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.
Muchen YuDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.
Manming XuDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.
Sergio DecherchiData Science and Computation Facility, Fondazione Istituto Italiano di Technologia, Via Morego 30, Genoa 16163, Italy.ORCID 0000-0001-8371-2270
Magdalena A TaracilaDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5029, United States.
Andrea M HujerDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5029, United States.ORCID 0009-0001-3543-1826
Christopher R BethelDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5029, United States.
Robert A BonomoDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5029, United States.ORCID 0000-0002-3299-894X
Shozeb HaiderDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.ORCID 0000-0003-2650-2925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of β-lactamase-mediated resistance poses a threat to β-lactam antibiotics. Boron-based β-lactamase inhibitors (BLIs) represent a promising class of reversible covalent inhibitors, yet the molecular basis of their recognition and dissociation remains poorly understood. Using

Indexed as

beta-Lactamase Inhibitorsbeta-LactamasesBoronic AcidsDrug DesignKineticsModels, MolecularStructure-Activity Relationshipbeta-Lactamase Inhibitorsbeta-LactamasesBoronic Acids

Identifiers

PMID41838618
PMCPMC13036776

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.