Evidence map›Paper›PMID 41838298›Full record

ArticleDiscover oncology2026

Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning.

Reza Shaghaghi Shahr, Mohaddese Sadat Mahmoudi, Nasim Amirnia, Fatemeh Karimpour, Atefeh Noori, Amir Khanmirzaei, Tabasom Hassania, Bahar Karimikhoshnoudian, Paniz Nasiri, Amir-Reza Javanmard

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Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Reza Shaghaghi ShahrDepartment of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohaddese Sadat MahmoudiDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University Tehran, Tehran, Iran.
Nasim AmirniaTehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Fatemeh KarimpourCancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Atefeh NooriDepartment of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran.
Amir KhanmirzaeiSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tabasom HassaniaDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University Tehran, Tehran, Iran.
Bahar KarimikhoshnoudianTehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Paniz NasiriProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Amir-Reza JavanmardSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. j.amirreza@modares.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is a major cause of morbidity and mortality worldwide. Early detection and diagnosis are critical for effective treatment, and the identification of prognostic biomarkers is essential for predicting patient outcomes. Recent advances in machine learning have enabled researchers to analyze large datasets of genomics and clinical data to identify novel biomarkers and therapeutic targets. In this study, we aim to examine the gene network and prognostic biomarkers involved in the onset of colorectal cancer in stool samples using machine learning. We will analyze data from a cohort of patients with colorectal cancer and healthy controls, including genomic data, clinical data, and stool samples. We will use a variety of machine learning techniques, including deep learning and network analysis, to identify patterns and relationships between genes, biomarkers, and clinical outcomes. Our preliminary results suggest that machine learning can be used to identify novel biomarkers and gene networks associated with the onset of colorectal cancer in stool samples. We have identified several candidate biomarkers that are significantly associated with disease progression and patient outcomes. These findings have the potential to improve our understanding of the molecular mechanisms underlying colorectal cancer pathogenesis and to identify new targets for therapy. In conclusion, our study demonstrates the feasibility and utility of using machine learning to analyze complex datasets of genomics and clinical data in the context of colorectal cancer. We anticipate that this approach will lead to the development of more accurate prognostic biomarkers and personalized therapies for patients with colorectal cancer.

Indexed as

BioinformaticsColorectal cancerLncRNAsmicroRNAsmRNAs

Identifiers

PMID41838298
PMCPMC13103136

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.