ArticleMolecular biology reports2026
Epigenetic insights into high-altitude-induced venous thromboembolism: methylation signatures in Indian population.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Venous thromboembolism at high altitude: mechanisms, risk stratification, and precision prevention.Frontiers in physiology · 2026Review
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8 authors.
Funding
Abstract
backgroundExposure to high-altitude (HA) conditions is associated with an increased risk of Venous Thromboembolism (VTE) due to hypobaric hypoxia. Although genetic factors contributing to this risk have been identified, the influence of epigenetic factors, such as DNA methylation, has not been investigated in Indian populations.
methodsThis study examined the association of specific DNA methyltransferase (DNMT) single nucleotide polymorphisms (SNPs) with high-altitude–induced VTE. The research cohort included high-altitude VTE patients (HA-VTE), high-altitude acclimatized controls (HAC), high-altitude natives (HAN), sea-level VTE patients (SL-VTE), and sea-level controls (SLC). Genotyping of seven DNMT SNPs was performed using TaqMan-based real-time polymerase chain reaction (RT-PCR). Statistical analysis was carried out to assess correlation with VTE risk using odds ratios (OR) and confidence intervals (CI).
resultsDNMT3B rs2424913 was strongly associated with increased VTE risk in HA-VTE compared with both acclimatized controls and high-altitude natives. In contrast, DNMT3B rs2424908 demonstrated a clear protective effect, particularly among HA-VTE patients relative to acclimatized controls. Similarly, DNMT1 rs16999593 exhibited a protective trend when comparing acclimatized controls to high-altitude natives, while DNMT3A variants showed no significant association.
conclusionDNMT3B polymorphisms appear to influence susceptibility to VTE in Indian populations under hypoxic stress at high altitude, underscoring their potential as genetic markers for personalized prevention and risk prediction strategies.
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