Evidence map›Paper›PMID 41838211›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Adopting a couples' approach to treating chronic cancer-related fatigue: a single-arm pilot trial of a web-based cognitive therapy for couples.

Mariët Hagedoorn, Fabiola Müller, Sophie I van Dongen, Rosalie A M van Woezik, Marrit A Tuinman, Melanie P J Schellekens, Marije L van der Lee

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Mariët HagedoornDepartment of Health Sciences, Section Health Psychology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 (HPC FA12), 9700 RB, Groningen, The Netherlands. mariet.hagedoorn@umcg.nl.
Fabiola MüllerDepartment of Health Sciences, Section Health Psychology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 (HPC FA12), 9700 RB, Groningen, The Netherlands.
Sophie I van DongenDepartment of Scientific Research, Helen Dowling Institute (Center for Psycho-Oncology), Bilthoven, The Netherlands.
Rosalie A M van WoezikDepartment of Scientific Research, Helen Dowling Institute (Center for Psycho-Oncology), Bilthoven, The Netherlands.
Marrit A TuinmanDepartment of Health Sciences, Section Health Psychology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 (HPC FA12), 9700 RB, Groningen, The Netherlands.
Melanie P J SchellekensDepartment of Scientific Research, Helen Dowling Institute (Center for Psycho-Oncology), Bilthoven, The Netherlands.
Marije L van der LeeDepartment of Scientific Research, Helen Dowling Institute (Center for Psycho-Oncology), Bilthoven, The Netherlands.

Funding

KWF Kankerbestrijding 12794
6 · The paper itself

Abstract

purposeMany cancer survivors experience chronic cancer-related fatigue (CCRF). While most psychosocial interventions focus exclusively on cancer survivors themselves, increasing evidence suggests that involving partners may enhance and broaden the benefits of these interventions. The primary objective of this study was to assess the acceptability and potential efficacy of COMPANION, a web-based mindfulness-based cognitive therapy for couples (15-20 weeks). Additionally, we examined the feasibility of the trial procedures.

methodsThis single-arm pilot trial included cancer survivors and their romantic partners. Participants completed questionnaires prior to starting the therapy (T0), 2 weeks after the therapy (T1), and 1 month following T1 (T2). Predefined benchmark values were used to assess the acceptability and potential efficacy of COMPANION, as well as the feasibility of the trial procedures.

resultsForty-six couples were screened for eligibility, 33 fulfilled the inclusion criteria and 21 entered the study. Seventy-one percent of the couples completed COMPANION (n = 15). Most couples were satisfied with the intervention and the couples' approach. About two-thirds of the cancer survivors showed a clinically relevant improvement in fatigue from T0 to T1. Improvement was also seen in anxiety and depressive symptoms in both members of the couples. The trial procedures were found to be feasible.

conclusionsBased on the benchmark values, we conclude that the intervention is acceptable and potentially efficacious. A randomized controlled trial is therefore warranted to further evaluate the effectiveness of COMPANION. IMPLICATIONS FOR CANCER SURVIVORS: After further testing, the intervention may be offered more broadly and complement much-needed psychosocial interventions to help couples cope with CCRF.

Indexed as

Cognitive Behavioral TherapyFatigueInternet-Based InterventionNeoplasmsAdultAgedAnxietyCancer SurvivorsChronic DiseaseDepressionFeasibility StudiesFemaleHumansInternetMaleMiddle AgedCancerChronic fatigueCouples therapyMindfulnessPsycho-oncologySingle-arm pilot

Identifiers

PMID41838211
PMCPMC12992381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.