ArticleMolecular biology reports2026
Silencing of a carboxylesterase gene NleFE4 in Indian brown planthopper biotype negatively impacts its performance and survival on rice.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRice productivity is severely challenged by the brown planthopper (Nilaparvata lugens Stål, BPH) infestations. Four different biotypes and multiple virulent BPH populations make the pest control even more challenging. Among these biotypes, the biotype 4 found in the Indian sub-continent is considered to be the most destructive. However, the molecular mechanisms of the BPH biotype 4 and rice interactions are explored to a limited extent.
methodsIn this study, the function of a carboxylesterase gene (NleFE4) in the BPH biotype 4 has been investigated via RNA intereference-mediated gene silencing during compatible (BPH fed on TN1 rice) and incompatible (BPH fed on PTB33 rice) rice-BPH interactions. In addition, the NleFE4 silencing effects on the BPH performance and survival were evaluated. Finally, interactions between NleFE4 and key rice secondary metabolites (sakuranetin, phenylpropane, epigallocatechin, spermidine, and quercetin) were predicted.
resultsAdministration of dsNleFE4 significantly reduced the NleFE4 expression in the BPH. The honeydew amount, BPH weight gain, and BPH survival assays suggested that silencing of NleFE4 negatively affected the BPH performance and survival. The molecular docking analysis results suggested that NleFE4 could interact with all five rice secondary metabolites with varied levels of binding affinities and could be involved in the detoxification of these metabolites during rice-BPH interactions.
conclusionSilencing of NleFE4 had detrimental effects on the BPH performance and survival. NleFE4 could be involved in the detoxification of key rice allelochemicals.
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