Evidence map›Paper›PMID 41838177›Full record

ArticlePediatric surgery international2026

Factors determining the surgical outcomes in infantile hypertrophic pyloric stenosis at Muhimbili National Hospital, Tanzania.

Rajabu Athumani Bakari, Ally Mwanga, Daniel Kitua, Nashivai Kivuyo, Alfred Chibwae, Meshack Brighton, Mohammed Sultan Salim, Kitembo Salum Kibwana

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Rajabu Athumani BakariDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania. rogerluhizo@gmail.com.
Ally MwangaDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania.
Daniel KituaDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania.
Nashivai KivuyoDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania.
Alfred ChibwaeDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania.
Meshack BrightonDepartment of Surgery, Muhimbili University of Health and Allied Sciences, P.O.BOX 65001, Dar es Salaam, Tanzania.
Mohammed Sultan SalimDepartment of Surgery, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Kitembo Salum KibwanaDepartment of Surgery, Muhimbili National Hospital, Dar es Salaam, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfantile hypertrophic pyloric stenosis (IHPS) is the most common surgical cause of non-bilious vomiting in infants, necessitating timely surgical intervention. Despite established treatment protocols, outcomes vary widely based on clinical and demographic factors.

aimThis study aimed at assessing the factors determining the surgical outcomes in IHPS at Muhimbili National Hospital (MNH). METHODOLOGY: This was a retrospective cohort study of 100 infants with intra-operatively confirmed IHPS who underwent pyloromyotomy between 2015 and 2024. Data on demographics, clinical presentation, biochemical markers, surgical details, complications, and outcomes were analyzed. Chi-square and multivariate logistic regression were applied to determine associations, with p < 0.05 considered statistically significant.

resultsIHPS constituted 12.24% of all pediatric laparotomies. The median age was 45 days, with a male to female ratio of 4.3:1. Vomiting (100%), weight loss (17%), and visible gastric peristalsis (21%) were common presentations. Electrolyte imbalances were frequent: hypokalemia (64%), hyponatremia (58%), and hypochloremia (66%). Surgical complications occurred in 30% of infants, with a mortality rate of 6%. Significant factors associated with prolonged hospital stay included preterm birth (AOR = 8.05, p = 0.032) and low hemoglobin (p = 0.040).

conclusionIHPS is a common and surgically manageable condition in infancy. However, preoperative factors such as prematurity and anemia significantly affect outcomes. Strengthening preoperative optimization could improve survival and reduce hospital stay.

Indexed as

Pyloric Stenosis, HypertrophicPyloromyotomyFemaleHumansInfantInfant, NewbornMalePostoperative ComplicationsRetrospective StudiesRisk FactorsTanzaniaTreatment OutcomeInfantile hypertrophic pyloric stenosisMucosal perforationOutcomeProlongedPyloromyotomy

Identifiers

PMID41838177

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