Evidence map›Paper›PMID 41838123›Full record

ArticleBulletin of environmental contamination and toxicology2026

Removal of Bisphenol A, Bisphenol S, and Estrogenic Activity from Real Wastewater Using a Multi-stage IFAS System.

Amanda F do Amaral, Alexandre S A da Silva, Deivisson L Cunha, Priscila M de O M Cunha, Rodrigo Coutinho, Marcia Marques

Abstract read
In one paragraph

Article in Bulletin of environmental contamination and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amanda F do AmaralDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil. amaral.amanda@posgraduacao.uerj.br.ORCID http://orcid.org/0000-0001-8339-3214
Alexandre S A da SilvaDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil.
Deivisson L CunhaDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil.
Priscila M de O M CunhaDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil.
Rodrigo CoutinhoDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil.
Marcia MarquesDepartment of Sanitary and Environmental Engineering, Rio de Janeiro State University (UERJ), São Francisco Xavier, 524, Rio de Janeiro, RJ, CEP 20550-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the removal of bisphenol A (BPA), bisphenol S (BPS), and estrogenic activity from real municipal wastewater using a pilot-scale multi-stage integrated fixed-film activated sludge (MS-IFAS) system. The configuration comprised five sequential reactors (Anaerobic, Anoxic-1, Aerobic under IFAS, Anoxic-2, and Re-aeration) providing distinct redox conditions. Influent concentrations averaged 112.6 ± 49.5 µg L−1 for BPA and 6.6 ± 3.0 µg L−1 for BPS. Overall removal efficiencies reached 99.8 ± 0.1% and 97.7 ± 1.0%, respectively, despite influent variability. The aerobic IFAS reactor was the main contributor to contaminant degradation, maintaining performance even after a > 90% biomass loss. Estrogenicity, assessed by the Yeast Estrogen Screen assay and expressed as 17β-estradiol equivalents (E2-EQ) decreased by 83.2% (0.031–0.005 ng L−1). Effluent E2-EQ values were below ecotoxicological thresholds, indicating negligible estrogenic risk to aquatic organisms. These highlight the strong potential of MS-IFAS for removal of xenoestrogenic contaminants in real wastewater.

Indexed as

Benzhydryl CompoundsEstrogensPhenolsSulfonesWaste Disposal, FluidWastewaterWater Pollutants, ChemicalBioreactorsBisphenol A CompoundsBisphenol S CompoundsEndocrine DisruptorsSewageBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol SBisphenol S CompoundsEndocrine DisruptorsEstrogensPhenolsSewageSulfonesWastewaterWater Pollutants, ChemicalBisphenol ABisphenol SEndocrine-disrupting compoundsIntegrated fixed-film activated sludgeWastewater treatmentYeast estrogen screen

Identifiers

PMID41838123
PMCPMC12992361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.