ArticleExperimental brain research2026
Binasal occlusion modulates cortical functional connectivity and hemodynamics in acquired paralytic esotropia: a fNIRS study.
Article in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To investigate the hemodynamic responses and functional connectivity patterns in the visual cortex of patients with acquired brain injury-related esotropia (ABI-ESO) following Binasal Occlusion (BNO) using functional near-infrared spectroscopy (fNIRS). Patients who were diagnosed with ABI-ESO as the ABI-ESO group, and healthy controls were enrolled as the control group. fNIRS was used to monitor cerebral oxyhemoglobin (HbO) concentrations during a visual stimulation task (black-and-white checkerboard) before and after BNO. Changes in activation levels and functional connectivity among visual-related regions were analyzed. Baseline analysis revealed that the ABI-ESO group had significantly lower Occipital Eye Field (OEF) activation and weaker functional connectivity compared to controls. Following BNO, we observed distinct cortical changes. Specifically, the ABI-ESO group exhibited increased activation in the left Parietal Eye Field (LPEF). In terms of functional connectivity, coupling strength decreased in the inter-hemispheric pathways between bilateral Frontal (LFEF–RFEF) and Parietal (LPEF–RPEF) Eye Fields post-intervention in the ABI-ESO group, suggesting a reorganization of the visual network. ABI-ESO is characterized by baseline cortical hypo-activity and network disruption. BNO therapy facilitates dorsal stream activity and modulates inter-hemispheric connectivity by suppressing maladaptive synchronization. These findings suggest that BNO functions as a neuro-modulatory intervention, offering a preliminary objective rationale for neuro-visual rehabilitation.
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