ArticleEuropean radiology2026
Analysis of fetal MRI data reveals no effect on liver maturation following prenatal alcohol exposure.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePrenatal alcohol exposure (PAE) of the fetus may result in physiognomic alterations and/or impediment of cognitive development, summarized as fetal alcohol spectrum disorders (FASDs). Although alcohol is metabolized in the liver, the effects of PAE on the fetal liver are unknown. MATERIALS AND
methodsFor this study, n = 21 prenatal MRIs of fetuses with PAE and n = 45 MRIs of fetuses without PAE were included. To assess macroscopic organ development, liver volumetry was conducted and compared to an established prenatal estimation formula. A texture-based radiomics analysis based on ensemble (random forest) and linear (L2-penalized logistic regression) models was conducted.
resultsPAE and non-PAE fetuses were age-matched (gestational age 27.4 [IQR 25.1-30.0] vs. 26.7 [25.4-29.3] weeks, p = 0.650). PAE had no effect on liver volume (normalized per gestational week, p = 0.971) or signal intensity (SI) in T1 (p = 0.574) and T2 (p = 0.104). MRI-derived liver volumetry correlated strongly with a gestational age-based volume estimation regardless of PAE (both r > 0.75, p < 0.001). A texture-based radiomics analysis was unable to discern between PAE and no-PAE fetuses (ROC-AUC = 0.43, 95% CI 0.29-0.57 for random forest, ROC-AUC = 0.40, 95% CI 0.31-0.60 for L2-penalized logistic regression).
conclusionPAE had no significant effect on signal intensity of the fetal liver, and gestational-age-adjusted liver volumes did not differ between fetuses with and without PAE, suggesting no relevant effect on organ development. Texture-based radiomics were unable to identify PAE. Hence, alterations of the liver in fetal MRI with known PAE warrant investigations for causes other than alcohol. KEY POINTS: Question Prenatal alcohol exposure can lead to morphological and neurocognitive changes in the fetus. The effect on the fetal liver is unknown. Findings No differences in fetal liver volume or signal intensity were found regarding alcohol exposure. Texture-based radiomics analysis was unable to discern between the two groups. Clinical relevance Fetal MRI and radiomics analysis were unable to detect effects of alcohol exposure on the fetal liver. Aberrations of the fetal liver on MRI in patients with a history of prenatal alcohol exposure warrant investigation for other causes.
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