Evidence map›Paper›PMID 41838091›Full record

ArticleNeuroradiology2026

Contra-lesional hippocampus in low grade glioma patients with no hippocampal infiltration - a study of structural remodelling.

Marcin Stański, Mikołaj Goralewski, Jacek Wątorek, Sylwia Antczak, Alicja Stańska, Antoni Tundak, Jakub Moskal, Sławomir Michalak, Katarzyna Katulska

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Marcin StańskiDepartment of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Poznań, Poland. mstanski@ump.edu.pl.
Mikołaj GoralewskiDepartment of Neurosurgery, Poznan University of Medical Sciences, Poznań, Poland.
Jacek WątorekDepartment of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Poznań, Poland.
Sylwia AntczakDepartment of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Poznań, Poland.
Alicja StańskaDepartment of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland.
Antoni TundakDepartment of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Poznań, Poland.
Jakub MoskalDepartment of Neurosurgery, Poznan University of Medical Sciences, Poznań, Poland.
Sławomir MichalakDepartment of Neurosurgery, Poznan University of Medical Sciences, Poznań, Poland.
Katarzyna KatulskaDepartment of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Poznań, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLow grade gliomas (LGGs) are slowly growing tumours that induce neuroplasticity. Previous studies have shown that hippocampal invasion by an LGG may induce enlargement of the contra-lesional hippocampus, including its grey matter volume (GMV) and subfield volumes. However, it is not clear whether similar changes may occur in patients with an LGG that does not invade the hippocampus. The goal of this study was to assess GMV and hippocampal subfields of the contra-lesional hippocampus in LGG patients with no hippocampal involvement.

methodsThis was a retrospective study. 3D T1-weighted magnetic resonance imaging scans of 30 LGG patients (17 left-sided, 13 right-sided) with no hippocampal invasion and 26 healthy controls were included. GMV was analysed using voxel-based morphometry, and hippocampal subfield volumes were analysed using FreeSurfer 6.0. In the analysis, we focused on regions reported in the literature to be enlarged in LGG with hippocampal infiltration.

resultsContra-lesional hippocampal GMV was significantly larger in the left-sided LGG group (T = 7.78, p < 0.001) and the right-sided LGG group (T = 6.39, p < 0.001). A larger hippocampal-amygdala transitional area (HATA) volume was observed in the right-sided LGG group (Benjamini-Hochberg false discovery rate (FDR) adjusted p = 0.04, Bonferroni corrected p = 0.04). In this group, GC-ML-DG head (the granule cell molecular layer of the dentate gyrus head) was also enlarged after FDR adjustment (p = 0.04) but was not statistically significant after Bonferroni correction (p = 0.05).

conclusionThe hippocampus contralateral to LGG may undergo structural remodelling even when the ipsilateral hippocampus is not affected by tumour infiltration.

Indexed as

Brain NeoplasmsGliomaHippocampusMagnetic Resonance ImagingAdultFemaleHumansImaging, Three-DimensionalMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessRetrospective StudiesBrain morphometryBrain volumetryGliomaHippocampusMagnetic resonance imagingNeuroplasticity

Identifiers

PMID41838091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.