Evidence map›Paper›PMID 41838085›Full record

ArticleIntensive care medicine2026

Neurotoxicity of ICU sedatives: we should end the surrogate debate and standardize long-term brain outcomes with a core neuro-outcome set.

Lukasz Szarpak, Dawid Aleksandrowicz, Katarzyna Karczewska, Katarzyna Kotfis

Registry-linked trialAbstract readLetter
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07710066 (AWAKE-ICU), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07710066 not yet recruitingnot on this map

AWAKE-ICU: Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients

TypeobservationalSponsorPatricia Rodriguez VillamizarRan2026 to 2028Enrolled500ConditionsCritical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and AnalgesiaArmsStructured Awakening Evaluation (SAE)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lukasz SzarpakHenry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, USA.ORCID http://orcid.org/0000-0002-0973-5455
Dawid AleksandrowiczClinical Department of Anesthesiology, Intensive Care, and Pain Management, Mazovian Specialist Hospital, Radom, Poland.ORCID http://orcid.org/0000-0002-4332-9960
Katarzyna KarczewskaClinical Department of Anesthesiology, Intensive Care, and Pain Management, Mazovian Specialist Hospital, Radom, Poland.ORCID http://orcid.org/0000-0001-9458-1157
Katarzyna KotfisDepartment of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center, Nashville, USA. katarzyna.kotfis@vumc.org.ORCID http://orcid.org/0000-0001-8430-1369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41838085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.