Trial reportAesthetic plastic surgery2026
Comparing Punch Excision Combined with Triamcinolone Acetonide and 5-Fluorouracil Injection and Manual Fractional Technology Combined with Triamcinolone Acetonide and 5-Fluorouracil Injection in Keloids: A Single-Blinded Randomized Clinical Trial.
Trial report in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundIn this study, we conducted a randomized controlled clinical trial to investigate the effectiveness and safety of punch excision versus manual fractional technology (MFT) in patients undergoing intralesional triamcinolone acetonide and 5-fluorouracil injection.
methodsPatients with keloid were randomly divided into two groups: One received punch excision combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (punch excision + TAC&5-FU), and the other received MFT combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (MFT + TAC&5-FU). Designed treatments and regular evaluations were conducted.
resultsThe significant improvement was observed in both groups. Regarding the effectiveness of different combined therapies, MFT combined with TAC&5-FU demonstrated a greater improvement of mVSS, POSAS, and DLQI without statistical differences when comparing with those of punch excision combined therapy. Likewise, the injection times and adverse events were generally similar across both groups.
conclusionThis study demonstrated that punch excision combined with TAC&5-FU, as well as MFT combined with TAC&5-FU, was promising therapeutic options for keloids without a notable difference in effectiveness and safety. LEVEL OF EVIDENCE I: A single-blinded randomized clinical trial. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.