ArticleJournal of acquired immune deficiency syndromes (1999)2026
Associations of Plasma and Breast Milk HIV RNA and Tenofovir Concentrations With Risk of Postnatal HIV Transmission During Breastfeeding Among Women With and Without ARV Exposure.
Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWe assessed the association of vertical HIV transmission during breastfeeding with HIV viral load (VL) and tenofovir (TFV) concentrations in maternal plasma and breast milk.
settingA case-control study nested within the IMPAACT multisite PROMISE trial.
methodsEach case (mother-infant pairs with infants with a positive HIV test) was matched to 2 controls (pairs with HIV-negative infants) by infant sex, study site, PROMISE component (postpartum randomization or observational follow-up), and maternal age. Maternal plasma and breast milk collected near the case infant's infection date were assayed for RNA VL. TFV concentrations were measured in the subset of mothers who received a TFV-containing regimen. Odds ratios and 95% confidence intervals (CIs) were calculated using conditional logistic regression.
resultsThirty one cases and 62 controls included mothers with median age of 25 years. Median infant age at HIV diagnosis was 6 (3, 14) months. Plasma and breast milk RNA were above the lower limit of quantification (LLOQ) in 28 of 31 (90%) and in 17 of 31 (55%) maternal cases vs. 25 of 62 (45%) and 7 of 62 (11%) controls. Odds of vertical transmission were 9.1 (95% CI: 2.67 to 30.88) times higher for plasma RNA VL > LLOQ and 9.4 (95% CI: 2.73 to 32.58) times higher for breast milk RNA VL > LLOQ compared with RNA VL ≤ LLOQ. Among mothers who received a TFV-containing regimen, only 3 of 14 (21%) cases had detectable TFV concentrations in their plasma and breast milk vs. 31 of 37 (84%) in plasma and 29 of 37 (78%) in breast milk for controls. In breast milk, the odds of being a case was 90% lower (95% CI: 0.01 to 0.76; P = 0.027; n = 31) for each log 10 increase in TFV.
conclusionsOdds of breast milk HIV-1 transmission is associated with higher maternal plasma and breast milk RNA VL and lower breast milk TFV concentrations.
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