Evidence map›Paper›PMID 41837651›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk.

Yun Jin Chen, Arlen Gaba, Hui-Wen Yang, Matthew Maher, Richa Saxena, Peng Li, Kun Hu, Lei Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun Jin ChenQueen's University School of Medicine, Kingston, ON, Canada.ORCID 0009-0000-3935-8841
Arlen GabaPerioperative Sleep and Brain Health Lab (PSBL), Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0009-1277-3055
Hui-Wen YangDepartment of Biomedical Engineering, Tzu Chi University, Hualien, Taiwan.ORCID 0000-0002-6847-3272
Matthew MaherCenter for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Richa SaxenaCenter for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2233-1065
Peng LiMedical Biodynamics Center, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4684-4909
Kun HuMedical Biodynamics Center, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0350-3132
Lei GaoPerioperative Sleep and Brain Health Lab (PSBL), Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1476-1460

Funding

Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2)R01AG093843 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lei Gao · 2026 to 2026
$1.0M
Harnessing Sleep and Biological Rhythms to Improve Postoperative RecoveryR35GM160254 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Lei Gao · 2025 to 2026
$908k
A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)R03AG087439 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GAO, LEI · 2024 to 2025
$268k
NIA NIH HHS R01 AG093843NIA NIH HHS R03 AG087439NIGMS NIH HHS R35 GM160254
6 · The paper itself

Abstract

BackgroundPostoperative delirium (POD) affects up to a third of older surgical patients, leading to significant morbidity, mortality, and potential progression to Alzheimer's disease (AD). Polygenic risk scores (PRS) capture inherited susceptibility to complex diseases, but their relevance to POD is unclear.ObjectiveWe examined whether higher AD-PRS predict increased POD risk in patients without dementia and whether sleep burden modifies this relationship.MethodsThis study included 345 414 UK Biobank participants (mean [

Indexed as

Alzheimer DiseaseDeliriumPostoperative ComplicationsAdultAgedAged, 80 and overFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedRisk FactorsAlzheimer's diseaseperioperative periodpolygenic risk scorepostoperative delirium

Identifiers

PMID41837651
PMCPMC13409415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.