Evidence map›Paper›PMID 41837580›Full record

ArticleThe Journal of physiology2026

α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons.

Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giulia TomagraDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Anthony BattagliaDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Claudio FranchinoDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Sara BonzanoDepartment of Life Sciences and Systems Biology and "NICO" Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Turin, Italy.
Federico PicolloNIS Interdepartmental Centre, University of Torino, Turin, Italy.
Giuseppe ChiantiaDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Antonio de IureUniversity San Raffaele, Roma, Italy.
Paolo CalabresiNeurological Clinic, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Barbara PicconiUniversity San Raffaele, Roma, Italy.
Emilio CarboneDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Silvia De MarchisDepartment of Life Sciences and Systems Biology and "NICO" Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Turin, Italy.
Andrea MarcantoniDepartment of Drug and Science Technology, University of Torino, Turin, Italy.
Valentina CarabelliDepartment of Drug and Science Technology, University of Torino, Turin, Italy.

Funding

Compagnia di San PaoloItalian MUR, Ricerca CorrenteMinistry of University and Research (MUR)PRIN PNRR MUR2022 P2022CRAXJSupported by NGEU and funded by MUR (pnrr) MNESYS (PE0000006) DN. 1553 11.10.2022
6 · The paper itself

Abstract

The spontaneous firing activity of substantia nigra (SN) dopaminergic (DA) neurons is finely tuned by the autocrine inhibition mediated by D2 DA autoreceptors (D2-ARs) that activate GIRK2 channels. Despite this regulatory mechanism, the vulnerability of SN DA neurons may nevertheless increase due to an altered spontaneous firing activity of DA neurons, Ca

Indexed as

Action Potentialsalpha-SynucleinCalcium Channels, N-TypeDopamineDopaminergic NeuronsMesencephalonAnimalsCells, CulturedSubstantia Nigraalpha-SynucleinCalcium Channels, N-TypeDopaminealpha‐synucleinCav2.2. channelsdiamond‐based micro‐electrode arraysquantal dopamine releasespontaneous firing

Identifiers

PMID41837580
PMCPMC13039254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.