Evidence map›Paper›PMID 41837496›Full record

ArticleThe Analyst2026

Utilizing Venturi effect for automated high-throughput droplet-MS from well plates.

Bridget E Murray, Roger C Diehl, Moritz Pott, Daniel A Holland-Moritz, Alison R H Narayan, Robert T Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bridget E MurrayDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. rtkenn@umich.edu.ORCID http://orcid.org/0000-0001-9865-9046
Roger C DiehlLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID http://orcid.org/0000-0003-3129-5027
Moritz PottBASF SE, 67056 Ludwigshafen am Rhein, Germany.
Daniel A Holland-MoritzProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, USA.ORCID http://orcid.org/0000-0003-4634-6122
Alison R H NarayanDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. rtkenn@umich.edu.ORCID http://orcid.org/0000-0001-8290-0077
Robert T KennedyDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. rtkenn@umich.edu.ORCID http://orcid.org/0000-0003-2447-7471

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-throughput screening is important in a diverse array of applications including drug discovery, synthetic reaction development, and enzyme engineering. Well plates are often used for sample preparation and containment in such applications, so analytical methods that are compatible with this format are required. Mass spectrometry (MS) is an attractive analytical technique for high-throughput analysis due to its potential for rapid, sensitive, selective, and label-free multiplexed measurements. Here, we present a method that uses the Venturi effect to withdraw droplet samples from a well plate and infuse them to the electrospray ionization (ESI) source of a mass spectrometer. The Venturi effect is generated by flow of nebulizing gas through a constriction at the outlet of the ESI source. The resulting negative pressure allows sample to be pulled to the ESI source

Identifiers

PMID41837496
PMCPMC12990301

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.