Evidence map›Paper›PMID 41837481›Full record

ArticleCurrent medicinal chemistry2026

Discovery of New Hydrazonothiazolines as Bovine and Human Carbonic Anhydrase-II Inhibitors:

Sobia Ahsan Halim, Majid Khan, Muhammad Tariq Shehzad, Fazal Mabood, Suraj N Mali, Srutee Rout, Afnan Jan, Abdullatif Bin Muhsinah, Zahid Shafiq, Hamdy Kashtoh and 2 more

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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Sobia Ahsan HalimNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Majid KhanNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Muhammad Tariq ShehzadInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Fazal MaboodInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
Suraj N MaliSchool of Pharmacy, D.Y. Patil University, Sector 7. Nerul, Navi Mumbai, 400706, India.
Srutee RoutAgricultural and Food Engineering Department, Indian Institute of Technology, IIT Kharagpur, West Bengal, 721302, Kharagpur, India.
Afnan JanDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Abdullatif Bin MuhsinahDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, 61441, Saudi Arabia.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Hamdy KashtohDepartment of Biotechnology, Yeungnam University, Gyeongsan, 38541, Gyeongbuk, Republic of Korea.
Ajmal KhanNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.

Funding

King Khalid University RGP2/573/45
6 · The paper itself

Abstract

introductionCarbonic Anhydrase II (CA-II) is crucial for several physiopathological processes, including bone calcification, osteoporosis, tumorigenicity, and epilepsy, among others. Usually, the intraocular pressure observed in glaucoma exacerbates the condition, and CA-II inhibitors have the potential to be used for the reduction of this pressure.

methodsMoreover, to search for novel CA-II inhibitors with high potency, a series of hydrazonothiazoline derivatives (5a-q) were synthesized. The inhibitory potency of our synthesized compounds was investigated for human and bovine CA-II through in-vitro and computational methods. The in vitro screening revealed that 5a-5f, 5g, 5h, and 5l have significant inhibitory action for bCA-II (IC

resultsThe molecular dynamics simulation, MMPBSA analysis, revealed that 5a has better stability in 1BN1 than 5h in 1V9E.

conclusionThose identified inhibitors could serve as a skeleton to design more potent CA-II inhibitors in the future.

Indexed as

Carbonic Anhydrase IICarbonic Anhydrase InhibitorsDrug DiscoveryHydrazonesMolecular Dynamics SimulationThiazolesAnimalsCattleHumansKineticsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipCarbonic Anhydrase IICarbonic Anhydrase InhibitorsHydrazonesThiazolescarbonic anhydrase IIdocking studiesenzyme inhibition testingHydrazonothiazolinesmechanistic experimentsmolecular dynamics simulation

Identifiers

PMID41837481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.