Evidence map›Paper›PMID 41837428›Full record

ArticleMicrobiology spectrum2026

Within-host co-evolution of KPC variants: plasmid-mediated dissemination of

Li Ding, Xiangbing Wu, Qiang Xie, Liting Liu, Bingshao Liang, Siquan Shen, Yan Guo, Jing Chen, Fupin Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li Ding *Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0001-1436-3668
Xiangbing Wu *Department of Laboratory Medicine, Wenzhou Central Hospital, Wenzhou, Zhejiang, China.
Qiang Xie *Department of Laboratory Medicine, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People's Hospital of Chuzhou), Chuzhou, Anhui, China.
Liting LiuZhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
Bingshao LiangClinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-6613-340X
Siquan ShenInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Yan GuoInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Jing ChenHangzhou Matridx Biotechnology Co., Ltd, Zhejiang, China.
Fupin HuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4493-0619

Funding

China Antimicrobial Surveillance Network 2020QD049National Natural Science Foundation of China 82172311National Natural Science Foundation of China 82302574
6 · The paper itself

Abstract

KPC variants are the primary cause of treatment failure in patients with IMPORTANCE: This study elucidates the critical molecular mechanism and evolutionary pathway of a novel KPC variant, KPC-194, that confers resistance to the last-resort antibiotic combination ceftazidime-avibactam in a high-risk

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaeDrug CombinationsEvolution, MolecularHumansMicrobial Sensitivity TestsPlasmidsThird Generation CephalosporinsWhole Genome SequencingAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug CombinationsThird Generation Cephalosporinsceftazidime-avibactamKPC-194KPC-2KPC variantsK. pneumoniae

Identifiers

PMID41837428
PMCPMC13055270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.