SynthesisAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2026
Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies.
Synthesis in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Antimicrobial effectiveness of intracanal medicaments againstFrontiers in oral health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The aim of this study was to synthesize evidence on the influence of Enterococcus faecalis on endodontic treatment failure and strategies for its elimination. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD420251022741). PubMed and SciELO were searched using PICO terms, and 76 studies (1997 and 2025) met the inclusion criteria. Reported E. faecalis prevalence ranged from approximately 4%-78%, depending on detection methods and sampling strategies. Canal isolates frequently expressed virulence factors, formed biofilms, and survived alkaline pH and nutrient limitation, with multidrug resistance reported. Chemo-mechanical preparation with sodium hypochlorite and EDTA, often combined with ultrasonic activation, reduced intraradicular bacterial load but achieved complete sterilization. In retreatment, two-visit protocols with intracanal medication improved microbiological outcomes, although calcium hydroxide efficacy depended on vehicle and duration. Adjunctive approaches showed mainly in vitro promise. Optimised disinfection and sealing remain essential.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.