ArticleThe Journal of organic chemistry2026
Direct Acylation of Alkyl and Aryl Bromides via Nickel-Catalyzed Aldehyde C-H Functionalization.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Direct Acylation of Alkyl and Aryl Bromides via Nickel-Catalyzed Aldehyde C-H Functionalization.The Journal of organic chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Aldehyde C-H activation followed by coupling of the acyl fragment with a functionalized reagent represents an attractive approach for the synthesis of functionalized ketones. Although this strategy has been utilized for the formation of ketones with diverse substitution patterns, the majority of approaches are tailored for the synthesis of ketones that possess aryl functionality derived from either or both substrates involved in the catalytic union. In this work, the development of acylation reactions of alkyl and aryl bromides to directly access ketones from aliphatic and (hetero)aromatic aldehydes is described. A key feature of the reactions is the thermal generation of acyl radicals via hydrogen atom transfer (HAT) with a peroxide-based HAT agent. In line with previous photochemical methods utilizing alternative HAT agents, judicious choice of tridentate (terpyridine) or bidentate (phenanthroline) ligands enables C(sp
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.