Evidence map›Paper›PMID 41837227›Full record

ArticleACS materials Au2026

3D-Printed Biohybrid PE/PCL Biphasic Osteochondral Plug for Knee Cartilage Repair.

Jiayi Guo, Asyraf Abbas, Clara Barbut, Eun Ju Park, Qifeng Lim, Tingyi See, Lincoln Liow, Biyan Zhang, Peili Teo

Abstract read
In one paragraph

Article in ACS materials Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiayi GuoInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.ORCID https://orcid.org/0000-0002-2636-8079
Asyraf AbbasInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Clara BarbutInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Eun Ju ParkInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Qifeng LimInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Tingyi SeeSingapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Singapore 138648, Republic of Singapore.
Lincoln LiowDepartment of Orthopaedic Surgery, Singapore General Hospital, 20 College Road, Academia, Level 4, Singapore, 169856, Republic of Singapore.
Biyan ZhangSingapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Singapore 138648, Republic of Singapore.
Peili TeoInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.ORCID https://orcid.org/0000-0002-6944-5345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biohybrid polyethylene (PE) and polycaprolactone (PCL) were used to regenerate cartilage and bone tissues for repair of knee joint defects. Biohybrid polyethylene was synthesized using ring-opening metathesis polymerization methods with polyethylene-containing macromonomer and arginylglycylaspartic acid (RGD), laminin-derived peptide A5G81 (AGQWHRVSVRWG), or hyaluronic acid-containing macromonomer. The resultant brush copolymers were formulated with ultrahigh molecular weight polyethylene to create formulations for testing with human chondrocyte assays. PE-RGD formulation was determined to be the most effective in causing statistically significant chondrocyte proliferation consistently. PCL-RGD was used to create the stem of the plug for osteogenesis. The materials were 3D printed using dual nozzle fused filament fabrication method to create a biphasic interlocking plug for

Indexed as

cartilage repairosteochondral plugpeptidepolycaprolactonepolyethylene

Identifiers

PMID41837227
PMCPMC12983096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.