ArticleInternational journal of surgery case reports2026
Pseudomyogenic hemangioendothelioma of the tibia: a case report.
Article in International journal of surgery case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction and importance: Pseudomyogenic hemangioendothelioma (PMHE) is a rarely metastasizing intermediate endothelial neoplasm. It typically presents as multiple, discontinuous nodules in the lower extremities of young adult males. Most cases present skin or soft-tissue tumors, but intraosseous lesions without soft-tissue involvement are extremely rare. We report a case of PMHE of the tibia, diagnosed with FOSB staining. Presentation of case: A 36-year-old man presented with pain in the lower left leg after exercise and at night. X-ray, SPECT/CT, and MRI revealed two discontinuous lytic lesions within the cortical bone of the left tibia. A curettage procedure was performed for biopsy, but a diagnosis could not be made for a long time. After further consultation, FOSB staining was positive in the nucleus, leading to a definitive diagnosis of PMHE. No recurrence or metastasis was observed 2 years after surgery. Clinical discussion: PMHE is a rare endothelial tumor, and cases limited to bone without soft tissue involvement are exceptional. Diagnosis is difficult because of overlap with myogenic and epithelioid tumors, but nuclear FOSB staining is a reliable marker. Although local recurrence is frequent, metastasis is rare, underscoring the importance of accurate diagnosis and long-term follow-up. Conclusion: This case highlights the importance of considering PMHE in the differential diagnosis of bone tumors, the utility of FOSB immunostaining in confirming the diagnosis, and the need for long-term follow-up given the high risk of local recurrence.
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