SynthesisFrontiers in medicine2026
Association of gastroesophageal reflux disease with the incidence of multiple cancers: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate whether gastroesophageal reflux disease (GERD) is associated with an increased incidence of multiple cancers through a robust meta-analysis. Methods: We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for observational studies published up to July 11, 2025. All statistical analyses were performed using R version 4.5.0. Results: A total of 17 studies were included. The pooled results indicated that GERD was significantly associated with an increased risk of lung cancer (OR = 1.33, 95% CI: 1.25-1.42), laryngeal cancer (OR = 1.75, 95% CI: 1.38-2.21), pancreatic cancer (OR = 1.30, 95% CI: 1.12-1.50), and esophageal cancer (OR = 1.70, 95% CI: 1.12-2.57). However, no significant association was found between GERD and colorectal cancer (OR = 1.04, 95% CI: 0.63-1.72). Conclusion: This meta-analysis suggests that GERD is associated with an increased incidence of multiple cancers. These findings will contribute to the clinical management of GERD patients, particularly in terms of cancer prevention and early screening.
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