Evidence map›Paper›PMID 41836882›Full record

ArticleNeurology. Genetics2026

Consequences of the Novel ALS-Associated

Guy A Rouleau, Ziqi Yu, Jay P Ross, Daniel Rochefort, Boting Li, Kate Bornais, Marvin Chum, Sali M K Farhan, Patrick A Dion

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Guy A RouleauMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0000-0001-8403-1418
Ziqi YuMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0009-0003-9205-5438
Jay P RossMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0000-0002-8183-2524
Daniel RochefortMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0009-0001-1657-7627
Boting LiMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0000-0003-3193-487X
Kate BornaisMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0009-0000-6095-5413
Marvin ChumDivision of Neurology, Department of Medicine, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-2252-0846
Sali M K FarhanMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0000-0001-5936-0957
Patrick A DionMontreal Neurological Institute-Hospital, QC, Canada.ORCID https://orcid.org/0000-0002-2099-954X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Recent studies have identified variants in the kinesin family member 5A ( Methods: Induced pluripotent stem cells (iPSCs) were generated from siblings with and without the c.2993-6C > A variant. RT-PCR was performed on RNA extracted from iPSC-derived neurons to assess exon 27 splicing. Functional studies were conducted on iPSC-derived motor neurons (MNs). Results: RT-PCR confirmed that the c.2993-6C > A variant induced exon 27 skipping in Discussion:

Identifiers

PMID41836882
PMCPMC12983328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.