ReviewFrontiers in bioengineering and biotechnology2026
Research progress on osseointegration performance of porous structure-modified titanium alloy implants.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Porous Ti-6Al-4V Architectures in Load-Bearing Orthopedic Reconstruction: A Critical Narrative Review of the Translational Gap Across Microstructure, Fatigue, Surface Function, and Clinical Failure Modes.Materials (Basel, Switzerland) · 2026Review
- Fabrication of TiOMicromachines · 2026Article
- Machine Learning and Artificial Intelligence in Metallic Orthopedic Implant Development: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large bone defects remain a major clinical challenge and often require load-bearing implants for reconstruction. Titanium alloys are widely used for bone defect repair because of their favorable mechanical properties and biocompatibility; however, their high elastic modulus and limited bioactivity can cause stress shielding and insufficient osseointegration. Porous architectures have therefore been introduced to tailor the elastic modulus and promote bone ingrowth. This review summarizes current clinical applications and unresolved challenges of porous titanium implants, and integrates recent preclinical evidence on manufacturing routes and key design parameters. We analyze how pore topology (periodic versus stochastic architectures), pore size, porosity, strut diameter, and multiscale designs affect osseointegration. Overall, the review provides design-oriented insights and highlights prospects and challenges for future preclinical and clinical research to improve the osseointegration of porous titanium implants.
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Registered trials
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