ArticleInternational journal of nanomedicine2026
Bioactive Platinum Nanozymes Accelerate Diabetic Wound Healing via Anti-Inflammation and Macrophage Polarization Modulation.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aims to develop a therapeutic agent that accelerates the healing of chronic diabetic wounds by harnessing the highly efficient enzyme-mimicking activity of platinum nanozymes, and to elucidate its underlying mechanisms, thereby offering new insights for the treatment of diabetic wounds. Methods: SHA-PtNPs were synthesized using sodium hyaluronate (SHA) as the carrier, and their structural features were characterized by XRD, TEM, XPS and FTIR. The composite was then applied to evaluate wound-healing efficacy in diabetic mice. Furthermore, H&E staining, immunofluorescence staining, and other analyses were employed to investigate its underlying mechanisms in promoting wound repair. Results: The results revealed that SHA-PtNPs significantly accelerated wound closure through multiple mechanisms: (1) effective suppression of inflammatory responses and related cytokine production; (2) promotion of TGF-β1 secretion and upregulation of CD31 and α-SMA expression, thereby enhancing angiogenesis and tissue contraction; and (3) induction of macrophage polarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype. Conclusion: These findings suggest that SHA-PtNPs, as a nanozyme-based material, hold great potential as an efficient therapeutic agent for diabetic wound healing, demonstrating a synergistic mechanism that integrates ROS regulation with immune microenvironment modulation.
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