ArticleInternational journal of nanomedicine2026
Cu-Cy Nps@ZIF-8@HA-Mediated Photodynamic Therapy for Cutaneous Squamous Cell Carcinoma.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- ZIF-8 Nanodrug Delivery Systems: Construction Strategies, Functional Modifications, and Advances in Synergistic Tumor Therapy.International journal of nanomedicine · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The complex tumor microenvironment poses an important challenge for the effective treatment of tumors, so it is important to develop efficient multimodal nanomaterials for tumor therapy. This study introduces a novel nanomaterial, Cu-Cy Nps@ZIF-8@HA (CNZH), based on zeolitic imidazolate framework-8 (ZIF-8) backbone. CNZH offers the combined merits of facile synthesis, environmental benignity, and effective therapeutic performance against cutaneous squamous cell carcinoma(cSCC). Patients and Methods: The photosensitizer Cu-cy Nps (Cu-Cy Nanoparticles) was initially synthesized and subsequently encapsulated within a zeolitic imidazolate framework-8 framework to construct Cu-cy Nps@ZIF-8 (CNZ), which was further surface-modified with hyaluronic acid(HA) to yield the final nanocomposite CNZH. In vitro evaluations demonstrated excellent biocompatibility, as evidenced by hemolysis assays and CCK-8 cytotoxicity tests. Transmission electron microscopy (TEM) confirmed efficient cellular uptake by A-431 cells, while Western blot analysis validated its tumor-targeting specificity. Functional characterization revealed CNZH's remarkable capacity for reactive oxygen species(ROS) generation, GSH depletion, and singlet oxygen ( Results: This study successfully designed and fabricated a novel ZIF-8-based nanomaterial, CNZH, which exhibits POD, CAT, and GSH-Px enzymatic activities along with the capability to generate Conclusion: CNZH is expected to be a highly efficient nanomaterial for the synergistic treatment of cutaneous squamous cell carcinoma, thereby opening up a new avenue for the application of nanomaterials in the treatment of this malignancy.
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Registered trials
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