Evidence map›Paper›PMID 41836553›Full record

ArticleJournal of orthopaedic translation2026

VEGF-neutralized platelet-rich plasma with adipose-derived stromal vascular fraction enhanced osteochondral repair in a point-of-care goat model.

Shinsuke Kihara, Benjamin B Rothrauff, Tomoya Iseki, Kalon J Overholt, Yijen L Wu, Hang Lin, Peter G Alexander, Rocky S Tuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shinsuke KiharaCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Benjamin B RothrauffCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Tomoya IsekiCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Kalon J OverholtCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Yijen L WuDepartment of Pediatrics, and Rangos Research Center, Animal Imaging Core, University of Pittsburgh School of Medicine, USA.
Hang LinCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Peter G AlexanderCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Rocky S TuanCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/objective: Focal articular cartilage defects do not heal spontaneously. Platelet-rich plasma (PRP) is as an autologous source of growth factors that has been reported to promote tissue healing. However, PRP contains angiogenic factors such as vascular endothelial growth factor (VEGF) that are known to inhibit chondrogenesis and promote osteoarthritis progression. Mesenchymal stem cells (MSCs) have also shown promise in promoting focal cartilage repair, but MSC therapies typically require cell isolation and expansion before implantation in a second surgery. Adipose-derived stromal vascular fraction (SVF) is rich in MSCs and can be harvested and delivered in a single procedure. The purpose of this study was to determine the effect of VEGF-neutralized PRP on Methods: Adipose-derived MSCs (ASCs) were encapsulated in photocrosslinkable hydrogels supplemented with (1) Hanks' Balanced Salt Solution (HBSS), (2) PRP, (3) VEGF-neutralized PRP, or (4) transforming growth factor- β3 (TGF-β3) for Results: Conclusion: Neutralization of VEGF in PRP enhanced The translational potential of the article: This study suggests that tailoring PRP composition for specific pathologies may yield superior clinical effects. Notably, neutralization of angiogenic factors in PRP, such as VEGF, may enhance the efficacy of PRP in promoting osteochondral regeneration. Additional

Indexed as

Adipose-derived stem cellsCartilage repairGoat modelPlatelet-rich plasmaVEGF-neutralized PRP

Identifiers

PMID41836553
PMCPMC12988508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.