ReviewJournal of orthopaedic translation2026
Targeting synovial inflammation in knee osteoarthritis: translational insights for diagnosis and therapy.
Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Identification of diagnostic and prognostic hub genes in osteoarthritis: an integrated bioinformatics study.Clinical rheumatology · 2026Article
- Synovial Fluid Characteristics and Pain Recovery Trajectory Following Rehabilitation in Patients with Meniscal Tears: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Integration of gold standard arthroscopy, MRI and synovial histopathology outcomes for enhancing early knee osteoarthritis diagnosis.Aging clinical and experimental research · 2026Article
- Gut microbiota-immune crosstalk in osteoarthritis: pathogenic mechanisms and emerging therapeutic opportunities.Frontiers in microbiology · 2026Review
- Advancing the continuum of orthopaedic translation: Mechanistic insight, regenerative innovation, and converging technologies.Journal of orthopaedic translation · 2026Article
- Exploring the intricate relationship between IL-1β and IL-18 in the context of osteoarthritis.Frontiers in immunology · 2026Review
- What's next for osteoarthritis gene therapy?Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovial inflammation is a central feature of knee osteoarthritis (OA), linking systemic and local pathogenic pathways with clinical outcomes. This review synthesises current knowledge on synovial structure and function, and the molecular mechanisms that drive synovitis, including metaflammation, mechanoflammation, mechanotransduction, and immune cell polarisation. It further explores how these processes contribute to structural degeneration, pain, and disease progression. Diagnostic approaches are discussed, with emphasis on biochemical biomarkers, imaging modalities, and the limited reliability of pain alone as a disease marker. By integrating clinical phenotypes with molecular endotypes, the review features how precision medicine can reshape OA care. Therapeutic strategies are presented across the translational spectrum, from oral and intra-articular drugs in clinical use to emerging investigational therapies, multitargeting approaches, and novel gene therapies. This review advocates for phenotype- and endotype-informed interventions as a pathway to more effective and personalised management of synovitis-driven knee OA. The translational value of this work lies in integrating molecular mechanisms with clinical strategies to guide early diagnosis, refine therapeutic targeting, and inform the design of future trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.