Trial reportDrug design, development and therapy2026
Circadian Variation in Ropivacaine Requirement for Initiation of Epidural Labour Analgesia: A Random-Allocation Graded Dose-Response Study.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Purpose: There is evidence that labor pain and the doses of drugs used to treat it exhibit circadian variation. Previously, we reported that during the night, the effective dose (ED Patients and Methods: We recruited 150 nulliparous parturients requesting epidural labor analgesia during the day (day group, 07:01-19:00 h) and 150 during the night (night group, 19:01-07:00 h). Within each group, we randomly allocated patients to receive one of six doses of ropivacaine (7.5, 15, 22.5, 30, 37.5, or 45 mg) diluted to 20 mL to initiate epidural analgesia. Effective analgesia was defined as a visual analogue scale pain score of ≤ 3 cm (scale: 0--10 cm) within 30 min. We generated dose-response curves for ropivacaine using probit regression and estimated the values for ED Results: The estimated ED Conclusion: The time of day is an important factor that should be considered when selecting the dose of ropivacaine to initiate epidural labor analgesia. Trial Number and Registry Url: ChiCTR1900025381; https://www.chictr.org.cn/bin/project/edit?pid=42363.
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