Evidence map›Paper›PMID 41836503›Full record

ArticleResearch square2026

Untargeted serum metabolomics and air pollution in Parkinson's disease.

Dayoon Kwon, Kimberly C Pual, Yuyuan Lin, Danielle Thordarson, Jun Wu, Jason Su, Dean P Jones, Jeff M Bronstein, Beate Ritz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Dayoon KwonStanford University.
Kimberly C PualUniversity of California, Los Angeles.
Yuyuan LinUniversity of California, Los Angeles.
Danielle ThordarsonUniversity of California, Los Angeles.
Jun WuUniversity of California, Irvine.
Jason SuUniversity of California, Berkeley.
Dean P JonesEmory University.
Jeff M BronsteinUniversity of California, Los Angeles.
Beate RitzUniversity of California, Los Angeles.

Funding

PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Environment, Metabolomics, and PDR21ES030175 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2019 to 2020
$443k
A Multi-omics approach to Environment and Depression in Parkinsons disease (MOOD-PD)R21ES032593 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2021 to 2022
$429k
Environmental & Genetic Predictors of Parkinson's ProgressionR56ES026600 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2017 to 2017
$151k
NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R21 ES030175NIEHS NIH HHS R21 ES032593NIEHS NIH HHS R56 ES026600
6 · The paper itself

Abstract

Mechanisms linking air pollution to Parkinson's disease (PD) remain poorly understood despite consistent toxicological and epidemiological evidence. We investigated metabolic disturbances associated with air pollution in PD using untargeted metabolomics. Serum samples were collected from 616 PD patients and 271 controls residing in central California, a region with high air pollution. Exposures to particulate matter (PM

Identifiers

PMID41836503
PMCPMC12980367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.