ArticleJournal of medical biochemistry2026
Prediction value of cystatin C for postoperative acute kidney injury of acute type A aortic dissection.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to develop an early prediction model for postoperative acute kidney injury (AKI) in patients with acute type A aortic dissection (ATAAD) undergoing total a rch replacement (TAR) combined with frozen elephant trunk (FET) implantation. Specifically, it investigated the association between preoperative cystatin C levels and postoperative AKI while incorporating other relevant risk factors into the analysis. Methods: A single-centre case-control study was conducted, including 202 patients treated between January 2018 and December 2019. Patients were divided into an AKI group (n=73) and a non-AKI group (n = 129) based on postoperative renal outcomes. Results: Univariate analysis revealed that a preoperative history of hypertension (P = 0.013), white blood cell (WBC) count (P< 0.001), serum creatinine (P < 0.001), blood urea nitrogen (P < 0.001), and cystatin C (P< 0.001) were significantly associated with postoperative AKI. Postoperative variables, including duration of mechanical ventilation (P< 0.001), length of ICU stay (P< 0.001), acute respiratory failure (P = 0 .0 1 8 ), acute cerebrovascular events (P= 0.042), and 30-day mortality (P< 0.001) also differed significantly between groups. Multivariate logistic regression incorporating preoperative variables identified cystatin C (OR: 11.541, 95% CI: 3.811 -34.953 , P< 0.001), WBC count (OR: 1.122, 95% CI: 1.013-1.242, P= 0.028), and history of hypertension (OR: 3.080, 95% CI: 1.188-7.990) as independent risk factors for postoperative AKI. Survival analysis further confirmed a significant association between preoperative cystatin C levels and the incidence of AKI in both crude and subgroup analyses. A clinical prediction model was developed based on the multivariate results. Internal validation showed a concordance index (C-index) of 0.804 for the training set and 0.609 for the validation set. Conclusions: Preoperative cystatin C level was identified as an independent predictor of postoperative AKI. Incorporating cystatin C with other preoperative clinical risk factors may enhance the predictive accuracy for postoperative AKI in patients with ATAAD undergoing total arch replacement with FET implantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.