ArticleTherapeutic advances in urology
New-onset renal impairment following radical nephrectomy for renal cell carcinoma: a retrospective cohort study of clinical, intraoperative, and postoperative risk factors.
Article in Therapeutic advances in urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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11 authors.
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Abstract
Background: Radical nephrectomy is a recommended treatment for localized renal cell carcinoma when partial nephrectomy is not feasible. This approach is typically applied to patients with a normal contralateral kidney and no preexisting chronic kidney disease (CKD).The primary concern with surgery is its potential long-term impact on renal function. Objectives: To assess the risk of development of chronic kidney disease after radical nephrectomy. Design and methods: This is a retrospective cohort study of patients with normal preoperative renal function and contralateral kidney who underwent radical nephrectomy for cancer. At the last follow-up, patients were categorized according to CKD-EPI guidelines as having normal renal function grades G1-2 or impaired renal function grade ⩾G3a. Univariable and multivariable Cox regression analyses were used to identify the significant risk factors for CKD-free survival. Results: We included 135 patients, 49.1 SD 12.9 years old, 62 women (45.9%), and 73 men (54.1%). Preoperative weight was 81 SD 18 kg, and eGFR was 99.2 SD 19.2 mL/min/1.73 m Conclusion: Significant risk factors for renal impairment after radical nephrectomy were a decreased preoperative eGFR, intraoperative hypotension and, within 48h, postoperative eGFR. No other preoperative or intraoperative risk factor independently predicted CKD.
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