Evidence map›Paper›PMID 41836448›Full record

ReviewFrontiers in immunology2026

Advancing immunotherapy via multiple immune cells co-engagement.

Han Li, Yuxuan Zhang, Qiuyang Wei, Qimeng Sun, Feng Lin, Peng R Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Han Li *Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Yuxuan Zhang *Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Qiuyang WeiSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Qimeng SunSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Feng LinSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Peng R ChenPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has demonstrated remarkable clinical success in a wide range of malignancies, owing to its high specificity and durable therapeutic effects. However, its efficacy is constrained by multiple factors arising from the complex and heterogeneous tumor microenvironment (TME). Strategies capable of simultaneously and synergistically engaging multiple immune cells in TME represents a promising yet challenging frontier. Here we begin with a brief overview of current immune cell engagers harnessing the single immune cell types, such as T, NK cells and other immune cells. We then focus on the next generation of multiple immune cell-type co-engagement immunotherapies, discussing their targets, mechanisms, and therapeutic design. This review outlines both opportunities and hurdles of the multiple immune cell co-engagers, paving the way for more effective antitumor modalities.

Indexed as

ImmunotherapyNeoplasmsAnimalsHumansKiller Cells, NaturalT-LymphocytesTumor Microenvironmentantitumor immunotherapyimmune cell engagermultiple immune cell co-engagementmultispecific antibodytumor-immune microenvironment

Identifiers

PMID41836448
PMCPMC12982326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.