ArticleJRSM cardiovascular disease
Temporal change of lymphocyte subunits for maladaptive remodeling after anterior myocardial infarction.
Article in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objectives: Lymphocytes are key players in the adaptive immune system, playing an important role in the anti-inflammatory balance in the post-myocardial infarction (MI) period and being involved in healing process. We aimed to investigate temporal changes in lymphocyte subunits in maladaptive remodeling following acute myocardial infarction. Design and setting: A total of 84 patients with anterior ST-segment elevation MI (STEMI) were enrolled. Lymphocyte subunits were measured 1 day, 2 and 6 weeks after MI. Maladaptive cardiac remodeling was defined as an increase in left ventricular end-diastolic volume by ≥12% in cardiac magnetic resonance imaging at the 6-months follow-up. Participants: A total of 84 patients with anterior STEMI were enrolled. Measurements and results: On the first day post-MI, the median number of total lymphocytes, T cells, and B cells were higher in the maladaptive remodeling group than in the without maladaptive remodeling group. Two weeks post-MI, the median number of B cells was higher in the maladaptive remodeling group, but similar at 6 weeks post-MI. Regression analysis revealed that a high number of B cells on the first day post-MI was related to maladaptive remodeling. Conclusions: In the maladaptive remodeling group, both inflammation markers, T and B lymphocyte levels were higher in the initial phase of MI, while B cells were approximately two-fold higher and an independent predictor of maladaptive remodeling. This study strongly supports the idea of developing immunotherapies or treatments that target B cells in cardiac remodeling.
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