ArticleFrontiers in oncology2026
Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) characterized by a high risk of metastasis and poor prognosis. Current chemotherapy-based treatments are often limited by systemic toxicity and drug resistance. Brusatol (BRU), a natural compound with reported anti-tumor activity and low toxicity, has not been explored in the context of cancer metastasis or metabolic reprogramming. This study aimed to uncover the anti-metastatic mechanism of BRU by targeting the metabolic adaptation of detached TNBC cells. Methods: The suppressive effect of BRU was assessed via LDH release assays, trypan blue staining, tumor spheroid culture and spontaneous metastasis assays. To elucidate the underlying mechanisms, global metabolomics analysis, NADPH/NADP Results: BRU promoted membrane damage and cell death in extracellular matrix (ECM)-detached TNBC cells and suppressed metastasis Conclusions: These findings suggest that BRU targets metabolic plasticity in TNBC cells, highlighting its potential as an adjuvant therapy to enhance anti-tumor efficacy while reducing chemotherapy-associated toxicity.
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