ReviewBreast cancer (Dove Medical Press)2026
Ovarian Escape in Hormone Receptor-Positive Breast Cancer: Mechanisms, Risk Factors, Clinical Consequences, and Management Strategies.
Review in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Ovarian function suppression (OFS) is essential in the treatment of premenopausal patients with hormone receptor-positive breast cancer. However, during therapy with gonadotropin-releasing hormone analogs (GnRHa), some patients may experience a phenomenon known as "ovarian escape" in which levels of gonadotropins and estradiol return to premenopausal ranges, indicating partial or complete recovery of ovarian function. This phenomenon may markedly compromise the efficacy of endocrine therapy and increase the risk of breast cancer recurrence and disease progression. At present, there is no universally accepted or standardized definition for "ovarian escape" nor are there recognized diagnostic criteria. In clinical research, a serum estradiol threshold of 2.72 pg/mL is frequently employed as a reference standard for effective OFS. Systematic reviews have shown that different studies report varying incidence rates, diagnostic methods, and interpretations regarding its clinical significance, further adding to the complexity of this issue. Therefore, this review aims to systematically analyze key topics related to "ovarian escape" including its underlying mechanisms, potential risk factors, clinical consequences, and feasible management strategies, with the goal of providing scientific evidence and guidance for clinical practice.
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