Evidence map›Paper›PMID 41836077›Full record

ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2025

Fluorine-Thiol Displacement Stapling on the Disordered α

Carson B Cohen, Andrew J Andrews, Rongsheng E Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carson B CohenDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Andrew J AndrewsDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Rongsheng E WangDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.ORCID 0000-0002-5749-7447

Funding

The Role of Histone Chaperones in Histone Acetylation and Nucleosome DynamicsR01GM102503 · NIGMS · UNIVERSITY OF NORTH CAROLINA WILMINGTON · PI ANDREWS, ANDREW JOSEPH · 2014 to 2023
$3.9M
Steric-free labeling strategies to study disease-related non-histone substrates of post-translational modificationsR35GM133468 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Ross Wang · 2019 to 2026
$2.9M
NIGMS NIH HHS R01 GM102503NIGMS NIH HHS R35 GM133468
6 · The paper itself

Abstract

The development of high-affinity ligands specifically targeting intrinsically disordered protein interactions has remained challenging due to the lack of well-defined binding pockets and shallow binding surfaces commonly found at their interfaces. Here, we employed our fluorine-thiol displacement reaction (FTDR) peptide-stapling platform to synthesize a library of peptide-based ligands derived from the α

Indexed as

fluorine-thiol displacement reaction (FT-DR)intrinsically disordered proteins (IDPs)KIXphosphorylationpKIDstapled peptides

Identifiers

PMID41836077
PMCPMC12981611

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.