Trial reportInternational journal of chronic obstructive pulmonary disease2026
Enhancing Respiratory Support in COPD Patients with Nasal High Flow Using an Asymmetrical Cannula Interface: A Randomized Cross-Over Study.
Trial report in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Nasal high flow (NHF) is increasingly used in COPD patients with chronic respiratory failure. An asymmetrical cannula interface (AI) may enhance these benefits by combining increased airway pressure with reduced rebreathing from anatomical dead space. The aim of this study was to compare the effects of NHF using an AI versus a conventional symmetrical interface (SI) on tidal volume (Vt), respiratory rate (RR), minute ventilation (MV), gas exchange, and neuro-respiratory drive (NRD). Methods: Following a 15-minute baseline period, COPD patients recovering from acute exacerbation underwent two randomized 45-minute sessions of NHF therapy using either the AI or SI. All sessions were conducted during daytime in a semi-recumbent position. Ventilation was recorded using calibrated respiratory inductance plethysmography, and transcutaneous CO Results: In a group of 18 patients NHF significantly reduced RR and TcCO Conclusion: NHF reduced RR by increasing both expiratory and inspiratory times without altering the duty cycle. The lower MV during NHF with AI, accompanied by higher SpO
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