ArticleInternational journal of women's health2026
No Genetically Predicted Association Between Human Papillomavirus and COVID-19: A Mendelian Randomization Analysis in European Ancestry Population.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Purpose: Previous studies reveal that coronavirus disease 2019 (COVID-19) infection accelerates the progression of Human papillomavirus (HPV)-related diseases, but the results remain controversial. We conducted a bidirectional two-sample Mendelian randomization (MR) study to evaluate the causal association between HPV infection and COVID-19 using genome-wide association study (GWAS) summary data from European ancestry populations. Patients and Methods: Genetic summary data of HPV infection and COVID-19 were derived from the public GWAS meta-analysis and the COVID-19 host genetics initiative GWAS, respectively. The causal link between HPV infection and COVID-19 was evaluated by MR analysis with inverse variance weighting (IVW), MR-Egger, and weighted median methods. Additional MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) and MR-Egger regression methods were used to identify the potential pleiotropy of the instrumental variables (IVs). Bonferroni correction was used to account for the issue of multiple comparisons, leading to a statistically significant Results: There were no significantly causal links of HPV-16 or HPV-18 infection with COVID-19 infection, hospitalized COVID-19, or severe COVID-19 (all Conclusion: This study shows that COVID-19 infection does not affect the risk of HPV-16/18 infection, nor does HPV-16/18 infection increase COVID-19 infection risk. It highlights the need to maintain routine health management and no change to HPV prevention strategies.
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