Evidence map›Paper›PMID 41835724›Full record

ReviewCureus2026

Understanding Pediatric Stroke: Etiology, Diagnosis, and Management in Children Under 15 Years.

Dana AlZamer, Yazan S Al-Zamer, Majeed Al-Khafaji, Yousif M Basheer, Fatma Ahmed, Hameed Al-Khafaji, Basheer Basheer, Mohamed ElSerafi

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana AlZamerFamily Medicine, Jordan University of Science and Technology, Irbid, JOR.
Yazan S Al-ZamerGeneral Surgery, King Abdullah University Hospital, Irbid, JOR.
Majeed Al-KhafajiClinical Attachment, Al-Yarmouk Hospital, Irbid, JOR.
Yousif M BasheerMedical School, Ajman University, Ajman, ARE.
Fatma AhmedInternal Medicine, Ajman University, Ajman, ARE.
Hameed Al-KhafajiMedical School, Jordan University of Science and Technology, Irbid, JOR.
Basheer BasheerHospital-Based Medicine, HMS Al Garhoud Hospital, Dubai, ARE.
Mohamed ElSerafiNeurology, HMS Al Garhoud Hospital, Dubai, ARE.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although rare in children under the age of 15, stroke is associated with significant mortality and long-term neurological morbidity. Understanding its underlying etiologies, accurate diagnostic modalities, and appropriate management is crucial for improving patient outcomes. This narrative review article aims to summarize the current literature discussing the etiology, diagnosis, and management of stroke in children aged 15 years old or younger. A comprehensive literature review was done using scientific databases such as PubMed, Scopus, and Google Scholar. The literature search included publications from 1997 to 2023, including peer-reviewed articles that specifically targeted pediatric stroke in patients under the age of 15 years. Only articles that specifically mentioned pediatric stroke were considered, excluding articles that specifically targeted adult patients, with a focus on more recent evidence in the management and therapeutic sections. The review identifies cardioembolic sources, vascular abnormalities, hypercoagulable states, and infections as major etiologies of ischemic stroke in children. Hemorrhagic strokes, though less common, are primarily caused by trauma, aneurysms, and coagulopathies. While imaging modalities such as MRI and MR angiography have enhanced diagnostic accuracy, their availability is limited in resource-poor settings. Management is complicated by limited pediatric evidence supporting thrombolysis in pediatric ischemic stroke and the limited applicability of adult treatment guidelines. Pediatric stroke is a rare but formidable diagnostic and therapeutic challenge due to its varied etiologies and clinical presentations. Early recognition and intervention are key to improving outcomes. Future research should focus on refining diagnostic strategies and developing targeted therapies for pediatric patients.

Indexed as

brain ischemiacerebral hemorrhagehypercoagulabilitypediatric strokestroke management

Identifiers

PMID41835724
PMCPMC12983966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.