ArticleCureus2026
Bloodstream Infections in Intensive Care Units: Microbial Spectrum and Antibiogram From a Tertiary Care Hospital in Central India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundBloodstream infections (BSIs) are a major cause of morbidity and mortality among critically ill patients, particularly in intensive care units (ICUs). Increasing antimicrobial resistance among bloodstream pathogens further complicates management and limits effective empirical therapy.
methodsThis retrospective observational study was conducted in the Department of Microbiology at a tertiary care teaching hospital in central India. Blood culture samples received from various ICUs over a one-year period (July 2024 to June 2025) were analyzed. Organisms were identified using standard microbiological methods, and antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method in accordance with Clinical and Laboratory Standards Institute guidelines.
resultsOut of 740 blood culture samples processed, 245 (33.10%) yielded positive growth. Gram-negative bacilli were the predominant isolates (44.89%), followed by Gram-positive cocci (35.92%) and fungal pathogens (19.19%).
conclusionThis study highlights the predominance of Gram-negative pathogens and a substantial burden of multidrug resistance among ICU-associated BSIs. Regular surveillance of bloodstream pathogens and institution-specific antibiograms is essential to guide empirical therapy and support antimicrobial stewardship efforts in critical care settings.
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