Evidence map›Paper›PMID 41835680›Full record

ArticleCureus2026

Early Stroke in a Young Male: Could it be Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)?

Ajeet Raj, Sultan Ali, Muqaddas Imran, Karan Chaman Lal

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ajeet RajGeneral Internal Medicine, Northampton General Hospital NHS Trust, Northampton, GBR.
Sultan AliGeneral Internal Medicine, Northampton General Hospital NHS Trust, Northampton, GBR.
Muqaddas ImranGeneral Internal Medicine, Northampton General Hospital NHS Trust, Northampton, GBR.
Karan Chaman LalMedicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A man in his early 40s presented with a sudden-onset headache, slurred speech, drooling, and a transient left-sided facial droop, which resolved within a few hours. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare monogenic hereditary cerebrovascular disorder that can cause stroke in adults due to mutations in the NOTCH3 gene and is associated with characteristic white matter changes on imaging (the "NOTCH" part of the gene name is derived from the

Indexed as

blood pressurecerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil)dizzinessfacial droopheadachehypertensionnotch3 gene1slurred speechstroketongue-tie

Identifiers

PMID41835680
PMCPMC12987638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.